王鹏飞

发布者：王诗铭发布时间：2021-07-09浏览次数：4217

教师基本信息

姓名：王鹏飞

职称：青年研究员

电子邮箱：pengfei_wang@fudan.edu.cn

办公地点：永利集团304am官方入口E501-4


研究方向

长期从事新发传染病防治方面的研究，包括针对病毒的抗体和药物筛选、疫苗评估以及艾滋病的功能性治愈研究等。课题组常年招收博士后、研究生，欢迎咨询。


个人简介

男，1987年出生，博士、青年研究员、博士生导师。2006-2010年就读于北京师范大学获得学士学位；2010-2015年就读于永利集团304am官方入口并获得博士学位； 2015-2019年于美国洛克菲勒大学从事博士后研究；2020-2021年任美国哥伦比亚大学助理研究员，2021年7月起任永利集团304am官方入口青年研究员、博士生导师；2021年10月起任上海市重大传染病和生物安全研究院双聘PI。2021年入选国家海外高层次人才青年项目和上海市领军人才、启明星（A类），2022年获“上海科技青年引领35人计划”提名奖。


招生专业

遗传学、微生物学、免疫学


代表性论文和论著

  1. Chen Y, Zhao X, Zhou H, Zhu H, Jiang S, Wang P#. Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses. Nature reviews immunology.2022. doi: 10.1038/s41577-022-00784-3

  2. Ai J, Wang X, He X, Zhao X, Zhang Y, Jiang Y, Li M, Cui Y, Chen Y, Qiao R, Li L, Yang L, Li Y, Hu Z, Zhang W, Wang P#. Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2 and BA.3 sub-lineages. Cell Host & Microbe, 2022 10;30(8):1077-1083.e4.

  3. Wang X, Ai J, Li X, Zhao X, Wu J, Zhang H, He X, Zhao C, Qiao R, Li M, Cui Y, Hu Z, Xu C, Zhang W, Wang P#. Neutralization of Omicron BA.4/BA.5 and BA.2.75 by Booster Vaccination or BA.2 Breakthrough Infection Sera. Cell Discovery, 2022. in press

  4. Wang X, Zhao X, Song J, Wu J, Zhu Y, Li M, Cui Y, Chen Y, Yang L, Liu J, Zhu H, Jiang S, Wang P#. Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies.Emerging Microbes & Infections. 2022;11(1):477-481.

  5. Zhao X, Li C, Chiu MC, Qiao R, Jiang S, Wang P#, Zhou J#. Rock1 is a novel host dependency factor of human enterovirus A71: implication as a drug target. Journal of Medical Virology. 2022. doi: 10.1002/jmv.27975.

  6. Wang X, Zhao X, Cui Y, Qiao R, Li M, Chen Y, Yang L, Jiang S, Wang P#. Neutralization of distinct Omicron sublineages by longitudinal vaccination sera. Journal of Medical Virology 2022. doi: 10.1002/jmv.28017.

  7. Wang P*, Nair MS*, Liu L*, Iketani S*, Luo Y, Guo Y, Wang M, Yu J, Zhang B, Kwong PD, Graham BS, Mascola JR, Chang JY, Yin MT, Sobieszczyk M, Kyratsous CA, Shapiro L, Sheng Z, Huang Y, Ho DD. Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7. Nature.2021, 593, 130–135.

  8. Wang P*#, Casner RG*, Nair MS*, Wang M, Yu J, Cerutti G, Liu L, Kwong PD, Huang Y, Shapiro L#, Ho DD#. Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization. Cell Host & Microbe, 2021,29 (5), 747-751. e4.

  9. Liu L*, Wang P*(Equal contribution), Nair MS*, Yu J*, Rapp MA*, Wang Q*, Luo Y, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, Kwong PD, Sodroski JG, Yin MT, Sheng Z, Huang Y, Shapiro L, Ho DD. Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike. Nature, 2020, 584, 450–456.

  10. Han Y*, Duan X*, Yang L*, Nilsson-Payant BE*, Wang P*(Equal contribution), Duan F*, Tang X*, Yaron TM*, Zhang T, Uhl S, Bram Y, Richardson C, Zhu J, Zhao Z, Redmond D, Houghton S, Nguyen D, Xu D, Wang X, Jessurun J, Borczuk A, Huang Y, Johnson JL, Liu Y, Xiang J, Wang H, Cantley LC, tenOever BR, Ho DD, Pan FC, Evans T, Chen HJ, Schwartz RE, Chen S. Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids. Nature. 2021, 589, 270–275.

  11. Wang P, Gajjar MR, Yu J, Padte NN, Gettie A, Blanchard JL, Russell-Lodrigue K, Liao LE, Perelson AS, Huang Y, Ho DD. Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti-HIV-1 IgG1 antibodies in vivo. PNAS. 2020, 117(30):18002-18009.

  12. Wang P, Casner RG, Nair MS, Yu J, Guo Y, Wang M, Chan JF, Cerutti G, Iketani S, Liu L, Sheng Z, Chen Z, Yuen KY, Kwong PD, Huang Y, Shapiro L, Ho DD. A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses.Emerging Microbes & Infections. 2022, 11(1):147-157.

  13. Wang P*, Liu L*, Nair MS*, Yin MT*, Luo Y, Wang Q, Yuan T, Mori K, Solis AG, Yamashita M, Lawrence J. Purpura LJ, Laracy JC, Yu J, Sodroski JG, Huang Y, Ho DD. SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease. Emerging Microbes & Infections. 2020, 9(1):2091-2093.

  14. Wang P. Anti-HIV Passive Immunization in Animal Models. Journal of HIV & Retro Virus. 2018, 4 (1): 4.

  15. Wang P, Lu P, Qu X, Shen Y, Zeng H, Zhu X, Zhu Y, Li X, Wu H, Xu J, Lu H, Ma Z, Zhu H. Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui. Scientific Reports. 2017, 25;7(1):9451.

  16. Wang P, Qu X, Zhou X, Shen Y, Ji H, Fu Z, Deng J, Lu P, Yu W, Lu H, Zhu H. Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency. Virology. 2015, 486:228-38.

  17. Wang P, Qu X, Wang X, Zhu X, Zeng H, Chen H, Zhu H. Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5′-LTR promoter. Gene Therapy. 2014, 21(5):490-495.

  18. Wang P, Qu X, Wang X, Liu L, Zhu X, Zeng H, Zhu H. As2O3 synergistically reactivate latent HIV-1 by induction of NF-κB. Antiviral Research. 2013, 100 (3): 688-697.

  19. Qu X*, Wang P*(Equal contribution), Ding D, Li L, Wang H, Ma L, Zhou X, Liu S, Lin S, Wang X, Zhang G, Liu S, Liu L, Wang J, Zhang F, Lu D, Zhu H. Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Research. 2013, 41 (16): 7771-7782.  

  20. Jiao Y*, Wang P*(Equal contribution), Zhang H, Zhang T, Zhang Y, Zhu H, Wu H. HIV-1 Co-Receptor Usage Based on V3 Loop Sequence Analysis: Preferential Suppression of CXCR4 Virus Post HAART? Immunological Investigations 2011, 40(6):597-613.