永利集团304am(中国)官方网站

王陈继

发布者：彭筱葳发布时间：2021-12-10浏览次数：4550

基本信息

职称：副研究员

电话：021-31246559

邮箱：chenjiwang@fudan.edu.cn
地址：永利集团304am官方入口C515室

个人简介

男，1981年出生，博士，副研究员，博士生导师。2004年毕业于四川大学理科创新班，获理学学士学位；2010年毕业于永利集团304am官方入口，获理学博士学位；2010年7月至2016年6月任永利集团304am官方入口科研助理（助理研究员）；2016年7月至2017年11月任永利集团304am官方入口青年副研究员，2017年12月任永利集团304am官方入口副研究员。近年来承担国家自然基金四项，重点研发计划子课题一项及校级课题二项。作为通讯作者在《Nature Medicine》、《Nature Communication》、《Science Advances》、《Cell Death& Differentiation》、《Nucleic Acids Research》、《Leukemia》和《Autophagy》等学术期刊发表论文20余篇。

主要研究方向

1. 研究恶性肿瘤高频突变基因（特别是泛素-蛋白酶体途径相关基因）在肿瘤中的作用机制，阐明其致癌机理，并探索其成为肿瘤 “精准治疗”分型依据和药物靶标的可能性；2. 研究泛素-蛋白酶体、自噬体、溶酶体、线粒体和囊泡运输等相关途径基因突变导致人类神经/代谢性遗传病、神经退行性疾病的分子机制及靶向治疗的策略。

授课情况

承担本科生课程《生命的基石-细胞概论》、《人类医学分子遗传学》的教学工作。

招生专业

遗传学

代表性论文和论著

1. Gao K^§, Shi Q, Gu Y, Yang W, He Y, Lv Z, Ding Y, Cao W, Wang C^§, Wan X^§. SPOP Mutations Promote Tumor Immune Escape in Endometrial Cancer via the IRF1–PD-L1 Axis. Cell Death Differ. 2022 Dec 8. doi: 10.1038/s41418-022-01097-7.

2. Wang Y, Wang H^§, Wang C^§. Lysosomal dysfunction, autophagic defects, and CLN5 accumulation underlie the pathogenesis of KCTD7-mutated neuronal ceroid lipofuscinoses. Autophagy. 2022. Nov 11:1-3.

3. Wang Y, Cao X, Liu P, Zeng W, Peng R, Shi Q, Feng K, Zhang P, Sun H, Wang C^§, Wang H^§. KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses. Sci Adv. 2022 Aug 5;8(31):eabm5578.

4. Gao K^§, Shi Q, Liu Y, Wang C^§. Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer. Autophagy. 2022 Aug;18(8):2013-2015.

5. Jiao D, Chen Y, Wang Y, Sun H, Shi Q, Zhang L, Zhao X, Liu Y, He H, Lv Z, Liu C, Zhang P, Gao K, Huang Y, Li Y, Li L^§, Wang C^§. DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs. Oncogene. 2022 May;41(21):3000-3010.

6. Shi Q, Jin X, Zhang P, Li Q, He H, Zhao X, Lv Z, Zhao S, Li Y, Gao K^§,Wang C^§. SPOP Mutations Promote p62/SQSTM1-dependent Autophagy and Nrf2 Activation in Prostate Cancer. Cell Death Differ.2022 Jun;29(6):1228-1239.

7. Zhang P^§, Gao K^§, Zhang L, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W^§, Wang C^§.CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation. Cell Death Differ. 2021 Nov 6. doi: 10.1038/s41418-021-00890-0.

8. Zhang J, Zhang L, Nie J, Lin Y, Li Y, Xu W, Zhao J, Zhao SM^§, Wang C^§.Calcineurin Inactivation Inhibits Pyruvate Dehydrogenase Complex Activity and Induces the Warburg Effect. Oncogene. 2021 Dec;40(49):6692-6702.

9. Zhang J, Kun Gao K, Xie H, Wang D, Zhang P, Wei T, Yan Y, Pan Y, Chen H, Shi Q, Yao Li Y, Zhao S, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, Wang L, Wang C^§, Huang H^§. SPOP mutation induces DNA methylation via stabilizing GLP/G9a. Nat Comm. 2021 Sep 29;12(1):5716.

10. Ma J, Shi Q, Cui G, Sheng H, Botuyan MV, Zhou Y, Yan Y, He Y, Wang L, Wang Y, Georges Mer^§, Ye D^§, Wang C^§, Huang H^§. SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. Nat Comm. 2021 Oct 1;12(1):5779.

11. Jin X^§, Qing S, Li Q, Zhuang H, Shen L, Li J, Qi H, Lin T, Lin Z, Wang J, Cao X, Yang J, Ma Q, Cong L, Xi Y, Fang S, Meng X, Gong Z, Ye M, Wang S^§, Wang C^§, Gao K^§. Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis.Nucleic Acids Res. 2021 Jul 9;49(12):6788-6803.

12. Zhang L, Zhang J, Liu Y, Zhang P, Nie J, Zhao R, Shi Q, Sun H, Jiao D, Chen Y, Zhao X, Huang Y, Li Y, Zhao JY, Xu W, Zhao SM^§, Wang C^§. Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex. Cell Death Dis. 2021 Jun 19;12(7):634.

13. Jin X, Shi Q, Li Q, Zhou L, Wang J, Jiang L, Zhao X, Feng K, Lin T, Lin Z, Zhuang H, Yang J, Hu C, Zhang L, Shen L, Lu Y, Zhu J, Wang H, Qi H, Meng X, Xi Y, Pan J, Fang S, Tian H, Zhou C, Zhang P, Gao K, Zhao S, Li Y, Gong Z, Wang C^§.CRL3-SPOP Ubiquitin Ligase Complex Suppresses the Growth of Diffuse Large B-cell Lymphoma by Negatively Regulating the MyD88/NF-κB Signaling. Leukemia. 2020 May;34(5):1305-1314.

14. Shi Q, Zhu Y, Ma J, Chang K, Ding D, Bai Y, Gao K, Zhang P, Mo R, Feng K, Zhao X, Zhang L, Sun H, Jiao D, Chen Y, Sun Y, Zhao S, Huang H, Li Y^§, Ren S^§, Wang C^§. Prostate Cancer-associated SPOP Mutations Enhance Cancer Cell Survival and Docetaxel Resistance by Upregulating Caprin1-dependent Stress Granule Assembly. Mol Cancer. 2019 Nov 26;18(1):170.

15. Gao K^§, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao S, Li Y, Zhang P^§, Wang C^§. iASPP–PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation. Cell Death Dis.2018 May 1;9(5):528.

16. Zhang P, Wang D, Ren S, Zhao Y, Gao K, Ye Z, Wang S, Lin D, Pang X, Pan C, Zhu Y, Yan Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Wang L, Wang Y, Chen Y, Sun Y^§, Wang C^§, Huang H^§. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017 Sep;23(9):1055-1062.

17. Zhang Y, Wang Y, Wei Y, Wu J, Zhang P, Shen S, Saiyin H, Wumaier R, Wang C^§, Yu L^§. Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells. Cancer Lett. 2016 Mar 1;372(1):101-9.

18. Peng J, Ma J, Li G, Zhang P, Gao K, Jin X, Wang C^§, Fan J^§. Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma. Cancer Lett. 2015 Dec 1;369(1):167-74.

19. Zhang P, Gao K, Jin X, Ma J, Peng J, Tang Y, Zhang Y, An J, Yan J, Dong Y, Huang H, Yu L^§,Wang C^§. Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α (ERα) protein turnover. Cell Death Dis.2015 Mar 12;6:e1687.

20. Gao K, Tang W, Wang D, Zhang P, Yu L, Wang C^§, Wu D^§. Front Signal-Dependent Accumulation of RHOA Inhibitor FAM65B at Leading Edges Polarizes Neutrophils.J Cell Sci.2015 Mar 1;128(5):992-1000.

21. Zhang P, Gao K, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L^§, Wang C^§. Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants. Hum Mutat. 2014 Sep;35(9):1142-51.

22. An J*, Wang C*, Deng Y, Yu L, Huang H. Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants. Cell Rep. 2014 Feb 27;6(4):657-69.

23. Xiao Q*, Qu K*, Wang C*, Kong Y, Liu C, Jiang D, Saiyin H, Jia F, Ni C, Chen T, Zhang Y, Zhang P, Qin W, Sun Q, Wang H, Yi Q, Liu J, Huang H, Yu L. HDGF-related protein-3 is required for anchorage-independent survival and chemoresistance in hepatocellular carcinomas. Gut. 2013 Mar;62(3):440-51.

24. Yang Y*,Wang C*, Zhang P*, Gao K, Wang D, Yu H, Zhang T, Jiang S, Hexige S, Hong Z, Yasui A, Liu JO, Huang H, Yu L. Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis. J Biol Chem. 2013 Jan 4;288(1):529-39.

25. Wang C*, An J*, Zhang P, Xu C, Gao K, Wu D, Wang D, Yu H, Liu JO, Yu L. The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. Biochem J. 2012 Jun; 1;444(2):279-89.

26. Zhang P*,Wang C*, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L. The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem. 2010 Mar 19; 285(12):8869-79.