姓名：付玉华
职称：青年副研究员
电子邮箱：fuyuhua@fudan.edu.cn
办公地点：公司江湾校区生科楼C221
办公电话：15721283660
个人简介
男，博士，青年副研究员，硕士生导师。2015年博士毕业于公司生物医学研究院（导师：文波），同年于公司脑科学研究院进行博士后训练（合作导师：鲁伯埙），2017年12月起任公司生命科学院青年副研究员。
研究方向
从事自噬与聚谷氨酰胺(PolyQ)疾病的研究：
（1）细胞自噬机制和功能研究;
（2）聚谷氨酰胺(PolyQ)疾病致病机制与治疗研究。
科研项目
主持国家自然科学基金面上项目（2019），做为骨干参与国家重大研究计划集成项目（2020）、国家重点研发计划（2021）和上海市科委重大项目（2020）。
获奖情况
长三角神经科学青年科学家奖，2020
招生专业
神经科学
表性论文和论著
(1) Yuhua Fu, Ningxie Chen , Ziying Wang , Shouqing Luo , Yu Ding , Boxun Lu. Degradation of lipid droplets by chimeric autophagy-tethering compounds. Cell Research, 2021 Sep;31(9): 965 -979.(封面论文）.
(3) Xiao-jing Li#; Yuan-yuan Zhang#; Yu-hua Fu#; Hao Zhang; He-xuan Li;Quan-fu Li; Hai-ling Li; Ren-ke Tan; Chen-xiao Jiang; Wei Jiang; Zeng-xia Li;Cheng Luo; Bo-xun Lu; Yong-jun Dang; Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex, Acta Pharmacologica Sinica, 2021, 42(1): 1-11. （#co-first author）.
(4) Yuhua Fu#; Peng Wu#; Yuyin Pan#; Xiaoli Sun#; Huiya Yang; Marian Difiglia; Boxun Lu; A toxic mutant huntingtin species is resistant to selective autophagy, Nature Chemical Biology, 2017, 13(11): 1152-1154. （#co-first author）.
(5) Meng Yu#; Yuhua Fu#; Yijiang Liang#; Haikun Song; Yao Yao; Peng Wu;Yuwei Yao; Yuyin Pan; Lixiang Ma; Saiyin Hexige; Yu Ding; Shouqing Luo; Boxun Lu; Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models, Cell Research, 2017, 27(12): 1441-1665.（#co-first author）.
(6) Yuhua Fu; Pin Lv; Guoquan Yan; Hui Fan; Lu Cheng; Feng Zhang; Yongjun Dang; Hao Wu; Bo Wen; MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells, Scientific Reports, 2015, 15(5):1-12.
Personal Information：
Name：Yuhua FU
Position：Young associated professor
Mail：fuyuhua@fudan.edu.cn
Office location：C221 of Life Science Building, Jiangwan Campus, Fudan University
Phone：15721283660
Personal profile: (education work experience, academic part-time job, research projects, awards, etc.)
Male, Doctor, Young associated professor, Master mentor. Dr FU received Ph.D. degrees from the Biomedical Institute of Fudan University in 2015（Training mentor: Bo Wen）. In the same year, he received postdoctoral training in the Institute of brain science of Fudan University（Training mentor: Boxun Lu）, and he has joined the school of life sciences of Fudan University as a young associated professor in since December 2017.
Research interest:
Autophagy and polyglutamine (polyQ) diseases
(1) The mechanism and function of autophagy;
(2) Polyglutamine (polyQ) disease pathogenesis and treatment.
Research projects: Preside over NSFC and participate in the national major research plan integration projects（2020）、national key R & D plan (2021) and major projects of Shanghai Science and Technology Commission (2020).
Honors & Awards:
Yangtze River Delta neuroscience Young Scientist Award, 2020
Major: Neuroscience
Representative papers and works:
(1) Yuhua Fu, Ningxie Chen , Ziying Wang , Shouqing Luo , Yu Ding , Boxun Lu. Degradation of lipid droplets by chimeric autophagy-tethering compounds. Cell Research, 2021 Sep;31(9): 965 -979.(封面论文）.
(2) Xiaodan Zhang, Xue Wen, Ismael Al-Ramahi, Juan Botas, Boxun Lu. Yuhua Fu *. Inhibition of HIPK3 by AST487 ameliorates mutant HTT induced neurotoxicity and apoptosis via enhanced autophagy. Neuroscience Bulletin,2021 Nov 5.
(3) Xiao-jing Li#; Yuan-yuan Zhang#; Yu-hua Fu#; Hao Zhang; He-xuan Li;Quan-fu Li; Hai-ling Li; Ren-ke Tan; Chen-xiao Jiang; Wei Jiang; Zeng-xia Li;Cheng Luo; Bo-xun Lu; Yong-jun Dang; Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex, Acta Pharmacologica Sinica, 2021, 42(1): 1-11. （#co-first author）.
(4) Yuhua Fu#; Peng Wu#; Yuyin Pan#; Xiaoli Sun#; Huiya Yang; Marian Difiglia; Boxun Lu; A toxic mutant huntingtin species is resistant to selective autophagy, Nature Chemical Biology, 2017, 13(11): 1152-1154. （#co-first author）.
(5) Meng Yu#; Yuhua Fu#; Yijiang Liang#; Haikun Song; Yao Yao; Peng Wu;Yuwei Yao; Yuyin Pan; Lixiang Ma; Saiyin Hexige; Yu Ding; Shouqing Luo; Boxun Lu; Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models, Cell Research, 2017, 27(12): 1441-1665.（#co-first author）.
(6) Yuhua Fu; Pin Lv; Guoquan Yan; Hui Fan; Lu Cheng; Feng Zhang; Yongjun Dang; Hao Wu; Bo Wen; MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells, Scientific Reports, 2015, 15(5):1-12.