教师基本信息：
姓名：孔星星
职称：教授
电子邮箱：kongxingxing@fudan.edu.cn
办公地点：永利集团304am官方入口D203室
办公电话：021-31246753
研究方向：
主要研究脂肪、肌肉的代谢和交互作用，具体包括运动中脂肪组织和骨骼肌之间是如何进行对话、运动改善糖尿病等代谢性疾病的分子机制、脂肪组织炎症与糖尿病发生的关系和机制、炎症因子干扰素调节因子4（IRF4）在除脂肪组织外其他组织中的作用。共计发表SCI论文近30 篇，论文他引超过1520 次。
个人简介：
教育经历
2006 – 2011，中国医学科学院&北京协和医学院，博士
导师：方福德教授
2001 – 2006，中国医科大学，医学本科
科研与学术工作经历
2021 - 至今，公司，永利集团304am官方入口，教授
2017 – 2021，美国加州大学洛杉矶分校，助理教授（Tenure-Track）
2015 – 2017，哈佛大学贝斯以色列女执事医学中心（美国），讲师
2011 – 2015，哈佛大学贝斯以色列女执事医学中心（美国），博士后导师：Evan Rosen教授
科研项目及获奖情况
1. 2021年，入选上海市人才计划
2. 2017: Scholarship of Keystone Symposium Adipose Tissue Biology (J5), Keystone, Colorado, USA.
3. 2015-2020: K99/R00 Pathway to Independence Award (K99/R00 DK106550-01), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Role: PI, Total: $927,000.
4. 2015-2019: NCRP Winter 2014 Scientist Development Award (15SDG25680028)– American Heart Association, Role: PI, Total: $ 308,000. (Declined)
授课情况：生理学专业前沿课程
招生专业：生理学、遗传学
代表性论文和论著：
1. Zhu X#, Yao T#, Wang R#, Guo S, Wang X, Zhou Z, Zhang Y, Zhou X, Zhang Y, Zhuo X, Wang RT, Li ZJ*, Liu T*, Kong X*. IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway. Advanced Science, 2020, 7(19): 2001502.
2. Wang R#, Tian H#, Guo D, Tian Q, Yao T*, Kong X*. Impacts of Exercise Intervention on Various Diseases in Rats. Journal of Sport and Health Science, 2020, 9(3): 211-227.
3. Kong X#*, Yao T#, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Tsai L, Kahn BB, Spiegelman BM, Liu T*, Rosen ED*. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metabolism, 2018, 28(4): 631-643.
4. Kong X, Banks AS, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED*. IRF4 is a key thermogenic transcriptional partner of PGC-1a. Cell, 2014, 158(1): 69-83.
5. Williams KW#*, Liu T#, Kong X#, Fakuda M#, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE, Elmquist JK. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism, 2014, 20(3): 471-482.
6. Berglund ED#, Liu T#, Kong X#, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Olson DP, Scherer PE, Lowell BB*, Elmquist JK*. Melanocortin-4 receptors in preg Williams KW,anglionic parasympathetic and sympathetic neurons differentially control energy balance and glucose homeostasis. Nature Neuroscience, 2014, 17(7): 911-3.
7. Eguchi J#, Kong X#,Tenta M, Wang X, Kang S, Rosen ED*. Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes, 2013, 62(10): 3394-3403.
8. Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F*, Chang Y*. Sirtuin 3, a new target of peroxisome proliferator-activated receptor-γ coactivator-1α, plays an important role in the suppression of reactive oxygen species. PLos One, 2010, 5(7): e11707. 至今被引用600多次
9. Kong X, Wang R, Liu X, Zhu L, Shao D, Chang Y*, and Fang F*. Function of SIRT1 in Physiology. Biochemistry (Moscow), 2009, 74(7): 703-708.
10. Kong X#, Fan H#, Liu X, Wang R, Liang J, Gupta N, Chen Y*, Fang F*, Chang Y*. Peroxisome Proliferator-Activated Receptor Coactivator-1 Enhances Antiproliferative Activity of 5-Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase. Mol Pharmacol, 2009, 76: 854-860.
Xingxing Kong
Title: Professor
Email: kongxingxing@fudan.edu.cn
Office address: Room D203, School of Life Sciences, Fudan University
Tel: 021-31246753
Research Interests
The main researchs focus on metabolism and crosstalk of fat and muscle. Specifically, it includes how adipose tissue and skeletal muscle conduct dialogue during exercise, the molecular mechanism of exercise to improve metabolic diseases such as diabetes, the relationship and mechanism of adipose tissue inflammation and diabetes, and the role of inflammatory factor interferon regulatory factor 4(IRF4) in other tissues except adipose tissue. A total of nearly 30 SCI papers have been published, and the papers have been cited more than 1,520 times.
Personal Profile
2021 – present, School of Life Sciences, Fudan University, Professor
2017 – 2021, University of California, Los Angeles, USA, Assistant Professor
2015 – 2017, Beth Israel Deaconess Medical Center, USA, Lecturer
2011 – 2015, Beth Israel Deaconess Medical Center, USA, Postdoctor
2006 – 2011, Chinese Academy of Medical Sciences & Peking Union Medical College, Doctor
2001 – 2006, Chinese Medical Sciences University, Bachelor Of medicine
Honors and Awards
1. 2015-2020: K99 Pathway to Independence Award (K99 DK106550-01), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Role: PI, Total: $ 643,656.
2. 2013-2015: American Heart Association (AHA) Postdoctoral Fellowship, USA, $ 89,100.
3. 2013: Scholarship of Keystone Symposium Adipose Tissue Biology (J5), Keystone, Colorado, USA.
4. 2008-2009: Recipient of a scholarship of Basic Medical School, Peking Union Medical College, Beijing, China.
5. 2007-2008: Recipient of a scholarship of Basic Medical School, Peking Union Medical College, Beijing, China.
Teaching: Frontier of Physiology
Admissions Major: Physiology, Genetics
Selected Publications
1. Zhu X#, Yao T#, Wang R#, Guo S, Wang X, Zhou Z, Zhang Y, Zhou X, Zhang Y, Zhuo X, Wang RT, Li ZJ*, Liu T*, Kong X*. IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway. Advanced Science, 2020, 7(19): 2001502.
2. Wang R#, Tian H#, Guo D, Tian Q, Yao T*, Kong X*. Impacts of Exercise Intervention on Various Diseases in Rats. Journal of Sport and Health Science, 2020, 9(3): 211-227.
3. Kong X#*, Yao T#, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Tsai L, Kahn BB, Spiegelman BM, Liu T*, Rosen ED*. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metabolism, 2018, 28(4): 631-643.
4. Kong X, Banks AS, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED*. IRF4 is a key thermogenic transcriptional partner of PGC-1a. Cell, 2014, 158(1): 69-83.
5. Williams KW#*, Liu T#, Kong X#, Fakuda M#, Deng Y, Berglund ED, Deng Z, Gao Y, Liu T, Sohn JW, Jia L, Fujikawa T, Kohno D, Scott MM, Lee S, Lee CE, Sun K, Chang Y, Scherer PE, Elmquist JK. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism, 2014, 20(3): 471-482.
6. Berglund ED#, Liu T#, Kong X#, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Olson DP, Scherer PE, Lowell BB*, Elmquist JK*. Melanocortin-4 receptors in preg Williams KW,anglionic parasympathetic and sympathetic neurons differentially control energy balance and glucose homeostasis. Nature Neuroscience, 2014, 17(7): 911-3.
7. Eguchi J#, Kong X#,Tenta M, Wang X, Kang S, Rosen ED*. Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes, 2013, 62(10): 3394-3403.
8. Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F*, Chang Y*. Sirtuin 3, a new target of peroxisome proliferator-activated receptor-γ coactivator-1α, plays an important role in the suppression of reactive oxygen species. PLos One, 2010, 5(7): e11707. 至今被引用600多次
9. Kong X, Wang R, Liu X, Zhu L, Shao D, Chang Y*, and Fang F*. Function of SIRT1 in Physiology. Biochemistry (Moscow), 2009, 74(7): 703-708.
10. Kong X#, Fan H#, Liu X, Wang R, Liang J, Gupta N, Chen Y*, Fang F*, Chang Y*. Peroxisome Proliferator-Activated Receptor Coactivator-1 Enhances Antiproliferative Activity of 5-Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase. Mol Pharmacol, 2009, 76: 854-860.